Endocrine Abstracts

Introduction: Type 2 diabetes results from insulin resistance and B-cell failure. Bariatric surgery is an effective therapeutic modality for type 2 diabetes. Indeed, it induces high remission rates through improved insulin sensitivity and secretion. While the critical role of skeletal muscle in glucose homeostasis has long been known, its role as an endocrine organ secreting peptides, called myokines, has recently been identified. Some of these myokines were shown to influence...

Background and aims: The contribution of myokines to improved glucose homeostasis induced by bariatric surgery is unknown. Our study aims to identify myokines potentially improving glucose homeostasis following bariatric surgery.Patients and methods: Obese insulin-resistant patients were evaluated before and 3 months after bariatric surgery, i.e. a sleeve gastrectomy or a Roux-en-Y gastric bypass (n62). Muscle biopsies were taken from vastus lat...

Purpose: Our study aims to identify myokines potentially involved in improved glucose homeostasis after bariatric surgery.Methods: Obese patients were evaluated before and 3 months after bariatric surgery. Insulin resistance was assessed using the Homeostasis Model Assessment (HOMA) test. Muscle biopsies were taken from vastus lateralis. Genes encoding myokines involved in glucose homeostasis were identified using RNA-sequencing. Changes in myokines expr...